IL-21R forms a complex with the common cytokine receptor g chain,gc,and mediates IL-21 signaling (3,4).Both IL-21R and the gc are necessary for the IL-21 function.IL-21 and its receptor activate JAK-STAT signaling pathway.IL-21R is expressed in spleen,thymus,natural killer (NK),T and B cell lines.
Oct 15,2008·For analysis of IL-21R expression,cells were stained with a monoclonal antiIL-21R antibody (MAB9911; RD Systems),the respective mouse IgG 1 isotype control (MAB002; RD Systems),a polyclonal antiIL-21R antibody (sc-32902),or the respective isotype control (sc-2027; both from Santa Cruz Biotechnology,Heidelberg,Germany); for Act1 is a negative regulator in T and B cells via direct Jul 16,2018·Deletion of IL-21R or blockade of IL-21 with an anti-IL-21 neutralizing antibody ameliorates the Cells were further incubated with primary antibodies (mouse anti-V5,rabbit anti
Rabbit anti Human interleukin-21 receptor antibody recognizes an epitope within the N-terminal (NT) region of human interleukin-21 receptor (IL-21R),a type I transmembrane protein and member of the type I cytokine receptor family,selectively expressed by lymphoid tissues,which acts as the receptor for IL-21.Interaction between IL-21R and IL-21 results in the activation of several Anti Mouse Interleukin-21 Antibody Bio-RadRabbit anti Mouse Interleukin-21 antibody recognizes mouse interleukin-21 (IL-21),a pleiotropic cytokine and member of the IL-15/IL-21 family,secreted by stimulated CD4+ T cells,wh
The membrane was incubated with rabbit anti-HMOX1 monoclonal antibody (Catalog # M00253) overnight at 4â,then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT.Anti-Human IL-21R (Extracellular Domain) - LeincoIn vivo Functional Grade Antibodies; SARS-CoV-2 (COVID-19) Primary Monoclonal Antibodies; Polyclonal Antibodies; Human Biosimilar Antibodies; Recombinant Proteins,Growth Factors Cytokines; Isotype Control Antibodies; Secondary Antibody Products; CODEX&Barcoded Antibodies; CODEX&Validated Antibodies
In vivo Functional Grade Antibodies; SARS-CoV-2 (COVID-19) Primary Monoclonal Antibodies; Polyclonal Antibodies; Human Biosimilar Antibodies; Recombinant Proteins,Growth Factors Cytokines; Isotype Control Antibodies; Secondary Antibody Products; CODEX&Barcoded Antibodies; CODEX&Validated AntibodiesAnti-IL-21 Antibodies InvitrogenIL-21 Antibodies IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT),T helper (Th) 17 and T follicular helper (TFH) cells.In TFH cells,IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3,which leads to additional transcriptional activation by Bcl6.
Listed below are anti-IL-21 antibodies from multiple suppliers.IL-21 is a reported alias name for the human gene IL22,or 'interleukin 22'.The 179-amino acid protein is a member of the IL-10 family.The cellular localization is predicted to be secreted.Glycosylation sites have been reported.Antibodies to the IL-21 antigen may be useful for Anti-IL-21 monoclonal antibody combined with liraglutide Anti-IL-21 antibody has been studied in clinical trials in T1DM and other autoimmune patients,and the safety and efficacy of it showed improvement of autoimmune disorders . However IL-21R
Rabbit Anti-Human/Mouse/Rat Interleukin 21 Receptor IgGy Antibody Selector Quickly search hundreds of thousands of antibodies available for purchase from VWR by selecting common antibody features like antigen symbol and name,reactivity,clonality,conjugation,host,and other key factors.Anti-IL-21R [ATR-107] Standard Size Ab01293-23Anti-IL-21R [ATR-107] Standard Size Ab01293-23.0 This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format,for improved compatibility with existing reagents,assays and techniques.
IL-21 receptor antibody can be used for detection of IL-21 receptor by Western blot at 1 ug/mL.An approximately 60 kDa band can be detected.For immunofluorescence start at 20 ug/mL.Antibody validated Western Blot in human samples and Immunofluorescence in human samples.All other applications and species not yet tested.Western Blot 60 kDaAnti-IL21 Receptor Antibody Rabbit anti-Mouse Polyclonal IL21 Receptor antibody LS-C83985 is an unconjugated rabbit polyclonal antibody to mouse IL21 Receptor (aa35-64).Validated for ELISA,Flow and IHC.
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21).It belongs to the type I cytokine receptors,and has been shown to form a heterodimeric receptor complex with the common gamma-chain,a receptor subunit also shared by the receptors for interleukin 2,4,7,9,and 15.Anti-IL21 antibody (GTX85088) GeneTexIL-21R forms a complex with the common cytokine receptor g chain,gc,and mediates IL-21 signaling (3,4).IL-21 and its receptor activate JAK-STAT signaling pathway.IL-21 is expressed in activated T cells,and HL-60 and THP-1 cell lines.IL-21 plays a role in the proliferation and maturation of
Translate this pageCD360 (IL-21 Receptor) Monoclonal Antibody (eBio4A9),Biotin,eBioscience 4 References 4 ReferencesAnti-IL21R Antibodies InvitrogenTranslate this pageCD360 (IL-21 Receptor) Monoclonal Antibody (eBio4A9),Biotin,eBioscience 4 References 4 References
Anti-Interleukin 21 Receptor antibodies are available from several suppliers.In humans,this protein is encoded by the gene IL21R.The protein may also be known as CD360,IMD56,NILR,IL-21 receptor,and novel interleukin receptor.Anti-Interleukin 21 Receptor Antibody ProductsAnti-Interleukin 21 Receptor antibodies are available from several suppliers.In humans,this protein is encoded by the gene IL21R.The protein may also be known as CD360,IMD56,NILR,IL-21 receptor,and novel interleukin receptor.
Anti-Interleukin-21 receptor (IL-21R) (Hu) from Rabbit - unconj.- Dianova Int.Anti-Ovalbumin polyclonal antibody (DPATB-H81858 PP-deficient TCR transgenic mice showed diminished anti-OVA IgA induction.Blockade of IL-5R signaling in vivo led to similar results with relatively weaker effects than that of IL-21R mAb administration.These results suggest that IL-21 and IL-5 play
Buy rabbit polyclonal antibody to mTOR (A13984).Applications WB,IHC and more.Reactivity Human,Mouse and more. 100% Guarantee FREE Shipping Chicken Anti-Rabbit IgG (H+L) (Biotin) (A63808) Berberine inhibits IL-21/IL-21R mediated inflammatory proliferation of fibroblast-like synoviocytes through the attenuation of PI3K Antibodies Secondary Detection Reagents - KerafastSearch By Product Type Antibodies Secondary Detection Reagents Buffers Chemicals Cell Culture Transfection Reagents Cells Tissue Samples DNA Vectors,Clones,Purified Nucleic Acids Libraries Kits Assays Labeling Detection Products PCR Products Proteins,Enzymes Peptides Services Virus Vectors and Particles Search By Research
BioBrea Production of Primary Sigma Antibody Reagents.Mouse monoclonal Antibodies,Rabbit Polyclonal anti human antigen tags A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-21R .This antibody is tested and proven to work in the following applications:Discovery and characterization of potent IL-21 Jan 25,2019·Interleukin-21 (IL-21),a member of the common cytokine receptor chain (c) family,is secreted by CD4+ T cells and natural killer T cells and induces effector function through interactions with the IL-21 receptor (IL-21R)/c complex expressed on both immune and non-immune cells.Numerous studies suggest that IL-21 plays a significant role in autoimmune disorders.
the specificity of the IL-21R antibody,an IL-21R blocking peptide was incubated with the IL-21R primary antibody (blocking peptide:antibody = 10:1 molar ratio).After rins-ing with phosphate-buffered saline (PBS),secondary anti-bodies including Alexa Fluor 555 donkey-anti-rabbit (1:200; cat.no.A-31572; Invitrogen,Carlsbad,CA),Alexa FluorExpression of interleukin-21,interleukin-21 receptor Jan 01,2009·The corresponding region of the rat IL-21R exhibits 71% sequence identity to human IL-21R.After washing,bound primary antibodies were detected with horseradish peroxidase-conjugated anti-rabbit IgG (DAKO,Hamburg,Germany),diluted 1:10,000 in 2.5% skimmed milk powder in TTBS.
Aug 07,2019·Then,the sections were washed with PBS for three times,incubated in 5% goat serum at room temperature for 10 min,and stained with primary antibodies rabbit anti-human IL-21 (Novus Biologicals),rabbit anti-human IL-21R (Abcam,MA,USA),or rabbit anti-human IL-17A (Abcam,MA,USA).The sections were stained with the antibodies at 4°C HRP Conjugated Rabbit Anti-Goat IgG Super Vision Assay KitPrimary Antibodies--Monoclonal Antibodies--Rabbit Monoclonal Antibodies ELISA Kits--PicoKine ELISA Kits--PicoKine Quick ELISA Kits--EZ Set ELISA HRP Conjugated Rabbit Anti-Goat IgG Super Vision Assay Kit (Boster Biological Technology,Pleasanton CA,USA,Catalog # SV0003-1) Epub 2017 ·The follicular helper T cell (Tfh) and IL-21 have been shown to play an important role in many autoimmune diseases.However,less is known about their role in Graves disease (GD).This study aimed to investigate the expression of Tfhs and related factors (IL-21,IL-21R,CXCR5,and CXCL13) in GD thyroid tissues and to explore the effect of IL-21 on thyroid follicular cells (TFCs).
Background IL-21R.Interleukin-21 (IL-21) and its receptor play an important role in the regulation of the immune system.IL-21 R,also called NILR (novel interleukin receptor),is a type I cytokine receptor with 4 conserved cysteine residues and an extracellular WSXWS motif.It is most closely related to IL-2 R beta,IL-4 R alpha,and IL-9 R.IFN regulates IL21 and IL21R expression in human NK Jun 03,2004·IFN also inhibited antiCD3 antibodyinduced expression of IL21R mRNA at 6 h .This effect,however,appeared to be transient,as at a 24h timepoint,antiCD3induced IL21R expression was at an equal level in the presence or absence of IFN .
Rabbit polyclonal IL 21R antibody Home.Primary Antibodies .View All Primary Antibodies ; Monoclonal AntibodiesIL-21 Antibody 200-401-B53Interleukin-21 (IL-21) is a secreted,type-I cytokine with immunoregulatory activity.Human IL-21 shares the common gamma-chain with IL-2,IL-4,IL-7,IL-9,and IL-15 proteins but,in addition,binds to a unique IL-21R alpha chain which triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3,followed by activation of the transcription factors STAT1 and STAT3.
IL-21 Receptor Antibody A novel cytokine related to IL-2 and IL-15 was recently identified and designated IL-21.The receptor for IL-21 (IL-21R,also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family.IL-21R forms a complex with the common cytokine receptor gamma chain,gammac,and mediates IL IL-21 and IL-21 Receptor Expression in Lymphocytes and Feb 01,2011·IL-21R and IL-21 oligoprobes were obtained from Exiqon labeled with Digoxigenin.25 Sections were processed for in situ hybridization cytochemistry as previously described.26 In brief,frozen tissue sections (10 m) were fixed for 11 minutes with 4% paraformaldehyde followed by treatment with proteinase K (Sigma-Aldrich,Dorset,UK) for 20 minutes at room temperature under RNase-free
nal or IL-21R rabbit polyclonal (ab13268; Abcam) antibod- ies,followed by staining with the Tyramide Signal Amplifi- cation kit with Alexa Fluor 488anti-mouse IgG (Invitrogen,IL-21,Human Protein - GenScriptAdditionally,IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells.IL-21 exerts its effect through binding to a specific type I cytokine receptor,IL-21R,which also contains the gamma chain (c) found in other cytokine receptors including IL-2,IL-4,IL-7,IL-9 and IL-15.
Rabbit Anti-Human/Mouse/Rat Interleukin 21 ReceptorIL-21R Antibody (AF596) Novus BiologicalsGoat Polyclonal Anti-IL-21R Antibody.Validated WB,Flow,CyTOF-ready,ICC/IF.Tested Reactivity Mouse.100% Guaranteed.
100 µg (0.5 mg/ml) affinity-purified rabbit anti-human IL-21R polyclonal antibody in phosphate buffered saline (PBS),pH 7.2,containing 50% glycerol,1% BSA,0.02% sodium azide.Purification Affinity purifiedIL-21R Antibody 5554 BioVision,Inc.100 µg (0.5 mg/ml) affinity-purified rabbit anti-human IL-21R polyclonal antibody in phosphate buffered saline (PBS),pH 7.2,containing 50% glycerol,1% BSA,0.02% sodium azide.Purification Affinity purified
Formalin-fixed and paraffin embedded mouse lymphoma labeled with Anti-IL-21R Polyclonal Antibody,Unconjugated (bs-2622R) at 1:200 followed by conjugation to the secondary antibody and DAB staining Lane 1 Mouse Thymus lysates probed with IL-21R Polyclonal Antibody,Unconjugated (bs-2622R) at 1:1000 dilution and 4C overnight incubation.IL-21R antibody (pAb) PromoCellRabbit Anti-Human Interleukin-21 Receptor
There are 10 IL21 Receptor antibody for ELISA,1 IL21 Receptor antibody for IHC-P.Among all these IL21 Receptor antibodies,there are 1 anti-IL21 Receptor mouse monoclonal antibodies ,1 anti-IL21 Receptor rabbit monoclonal antibodies ,8 anti-IL21 Receptor rabbit polyclonal antibodies .IL21 Receptor Antibodies Sino BiologicalThere are 10 IL21 Receptor antibody for ELISA,1 IL21 Receptor antibody for IHC-P.Among all these IL21 Receptor antibodies,there are 1 anti-IL21 Receptor mouse monoclonal antibodies ,1 anti-IL21 Receptor rabbit monoclonal antibodies ,8 anti-IL21 Receptor rabbit polyclonal antibodies .
The membranes were then incubated with primary antibodies (all at 1:1,000),followed by goat anti-rabbit horseradish peroxidase-conjugated secondary antibodies (1:5,000; cat.no.ab181658; Abcam) at room temperature for 1 h.IL21R Rabbit anti-Human,Mouse,Rat,Polyclonal Feb 15,2021·IL-21R forms a complex with the common cytokine receptor -gamma chain,-gammac,and mediates IL-21 signaling.Both IL-21R and the gc are necessary for the IL-21 function.IL-21 and its receptor activate JAK-STAT signaling pathway.IL-21R is expressed in spleen,thymus,natural killer (NK),T and B cell lines.IL-21 plays a role in the
IL-21 is a novel cytokine that was recently identified in human and mouse.It has significant homology to IL-2,IL-4,and IL-15.The receptor for IL-21 is a new member of the class I cytokine receptor family.IL-021R forms a complex with the common cytokine receptor g chain and mediates IL-21 signaling.Immunogen Anti-IL-21receptor antibodywas prepared from whole rabbitserum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 97 to 111 of human IL-21receptor precursor.anti-IL21 Receptor antibody Product No.ABIN6656222Was this helpful?Anti-IL-21R antibody (ab5980) AbcamMay 04,2021·Immunocytochemistry/ Immunofluorescence view photo of Antibodies,Primary Antibody,Primary Antibodies.Contact China
Oct 26,2011·Serum IL-21 levels of SS patients were assessed for correlations with laboratory data,including anti-nuclear antibody,anti-Ro/La antibodies,globulin,immunoglobulin (Ig) class,and IgG subclass.LSGs from 16 primary SS and 4 controls with sicca symptoms were evaluated for IL-21 and IL-21 receptor (IL-21R) expression by immunohistochemistry.Impact of interleukin-21 in the pathogenesis of primary correlations with laboratory data,including anti-nuclear antibody,anti-Ro/La antibodies,globulin,immunoglobulin (Ig) class,and IgG subclass.LSGs from 16 primary SS and 4 controls with sicca symptoms were evaluated for IL-21 and IL-21 receptor (IL-21R) expression by immunohistochemistry.Confocal microscopy was performed to further
Sep 28,2018·Compared with conventional B cells,B2R cells are more responsive to Toll-like receptor 7/9 and type I/II interferon treatment,display higher levels of MHCII and co-receptors,and depend on ILInterleukin21 Induces Proliferation and Proinflammatory Increased expression of IL21R in the synovial tissues and fibroblastlike synoviocytes (FLS) of rheumatoid arthritis (RA) patients.(A) Tissue sections from the synovium of RA patients and osteoarthritis (OA) patients were stained with an antiIL21 receptor antibody.
Background IL-21R.The interleukin-21 (IL-21) and its receptor appear to play important roles in the regulation of the immune system.IL-21 R,also called NILR (novel interleukin receptor) is a type I cytokine receptor with 4 conserved cysteine residues and an extracellular WSXWS motif.It is most closely related to IL-2 R beta and IL-4 R alpha.Order RayBiotech's Rabbit Anti-IL-21R Antibody on ZAGENORayBiotech Rabbit Anti-IL-21R Antibody() RayBiotech Rabbit Anti-IL-21R Antibody() Product Suggestions Loading.Contact Us FAQ.Log In.Log In.Marketplace.Extraction Electrophoresis PCR,Cloning Expression Sequencing Kits Reagents Antibodies Immunoassays
Synonym(s) Anti-IL-21R MDL Number MFCD04040424 Storage 20°C Compare this item SIGMA Anti-Interleukin-21 Receptor,N-Terminal antibody produced in rabbit ~0.5Primary Antibodies - KerafastPrimary Antibodies.Filter X.Your Selection Product Type IL-21R (1) IL-2R -chain (1) Human TNF alpha (2) None (Preimmune anti-serum from rabbits subsequently immunized with GalNAc-TVPAAWVA) (1) None (Preimmune anti-serum from rabbits
Sections were blocked for 30 min with secondary serum (10% in Tris-buffered saline) and then stained with primary antibodies,0.5% chicken antiIL-21 (Lifespan Biosciences) or prediluted mouse anti-CD4 ([1F6]; ab17131; Abcam) for 12 h at 37°C or overnight at 4°C.Upregulation of Interleukin 21 and Interleukin 21 Receptor Sep 05,2017·Sections were blocked in 10% normal goat serum (ZsBio Ltd.,China) for 30 min at room temperature.After draining the goat serum,the sections were then incubated with rabbit anti-IL-21 antibody (1:100 dilution,ab5978,Abcam,Cambridge,UK) or rabbit anti-IL-21R antibody (1:50 dilution,sc32902,Santa Cruz,California,USA) at 4°C overnight.
anti- IL21 antibody Catalogue No.FNab04251 Size 100µg Form liquid Purification Immunogen affinity purified Purity 95% as determined by SDS-PAGE Host Rabbit Clonality polyclonal Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 ,anti-Homo sapiens (Human) GZMB Antibody - CusabioAfter dewaxing and hydration,antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0).Section was blocked with 10% normal goat serum 30min at RT.Then primary antibody (1% BSA) was incubated at 4°C overnight.The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
IL-21R on B cells is upregulated in allergic rhinitis patients when compared to controls.IL-21/IL-21R may be involved in the regulation of allergic reactions through the inhibition of IgE.PMID 25007029; IL-21/IL-21R could act as potential biomarkers presenting earlyanti-IL21 Receptor anticorps Produit ABIN6571161Lapin IL21 Receptor Polyclonal anticorps pour WB.Order anti-IL21 Receptor anticorps ABIN6571161.